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兒童骨齡評(píng)估與終高預(yù)測(cè)方法初探
作者:王秀民,何美朵,王偉,王德芬【關(guān)鍵詞】 骨齡評(píng)估
【摘要】 目的 比較四種常用的骨齡評(píng)估法(BP、CHN、TW2、TW3)對(duì)骨齡評(píng)估結(jié)果的差異性;并比較用其對(duì)應(yīng)的成人身高預(yù)測(cè)PAH法(BP、CHN、TW2-葉氏、TW3)預(yù)測(cè)不同病種患兒成人身高結(jié)果與實(shí)獲終身高(NAH)的差異性。方法 身高測(cè)量用墻式測(cè)高器,手及腕部骨齡X線片投照按標(biāo)準(zhǔn)技術(shù),骨齡評(píng)估:使用上海瑞金醫(yī)院放射科設(shè)計(jì)的TW2、CHN骨齡評(píng)分軟件及GP圖譜,TW3根據(jù)TW2也用計(jì)算機(jī)輔助評(píng)估,用SPSS 10.0軟件,計(jì)量資料以(x±s)表示,做單因素方差分析(ANOVA),組間差異用LSD方法分析。結(jié)果 在各年齡四種骨齡評(píng)估法(GP、CHN、TW2、TW3)結(jié)果差異無(wú)顯著性(P>0.05);四種方法(BP、TW2-葉氏、CHN、TW3)預(yù)測(cè)終身高:BP法與預(yù)測(cè)終身高有正負(fù)相關(guān)即不同正相關(guān)性(R=0.95,P≤0.01),TW3與終身高也有正相關(guān)性R=0.923,P<0.01,如將患者分組,矮小組:TW2與NAH有差異(F=4.35,P=0.039),NAH與BP和CHN有相關(guān)性(R=0.918,P≤0.001),早熟組:三種方法(BP,CHN,TW2-葉氏),與NAH差異無(wú)顯著性,相關(guān)系數(shù)分別為R=0.981,P<0.01,R=0.982,P<0.01,R=0.988,P≤0.01;TS組:BP與NAH差異無(wú)顯著性(R=0.956,P<0.05),CHN與NAH不相關(guān)(R=0.623,P<0.05)。結(jié)論 (1)骨齡評(píng)估在小年齡(≤10歲),TW3與GP方法最接近。在大年齡評(píng)估中四種方法均可采用。(2)采用骨齡預(yù)測(cè)終身高TW3和BP法最接近NAH,但在不同疾病BP法更接近NAH。
【關(guān)鍵詞】 骨齡評(píng)估;近似終身高;預(yù)測(cè)終身高
Methods of childrens bone age assessment and prediction of adult height
【Abstract】 Objective To compare the different results of four common methods of bone age estimation (GP, CHN, TW2, TW3),and compare the differences between NAH and the predictive height by using the method of PAH (BP, CHN, TW2-Ye, TW3).Methods The heights were measured by instruments, and bone age of hand and wrist by X-ray according to standard technology. Bone age estimations were performed by using TW2, CHN bone age estimation software and GP map desired by Radiological Department of Shanghai Ruijin Hospital.TW3 estimation was done according to TW2 with computer assisting. Results was presented by χ2x±s. The software of SPSS 10.0 was used to statistically analysed with method of ANOVA. The differences among the groups were analysed by using the method of LSD. Results At different ages, the results of four methods of bone age estimation (GP, CHN, TW2, TW3) had no difference (P>0.05). BP method had positive correlation with predictive height (R=0.95,P≤0.01) and so was method of TW3 and predictive height (R=0.923, P≤0.01). Conclusion (1) At younger age (≤10 years old), the results of TW3 and GP are the closest to NAH. At elder age, we can use all the four methods to estimate the bone age. (2) For predicting height with bone age, the results of TW3 and BP are the closest to the NAH, but BP is closer to NAH if the child has any endocrine problems.
【Key words】 bone age assessment;near adult height;prediction of adult height
骨齡評(píng)估是評(píng)價(jià)兒童生長(zhǎng)發(fā)育的重要內(nèi)容,它能較準(zhǔn)確地反映機(jī)體的發(fā)育水平和成熟程度,骨齡評(píng)估既有助于某些疾病的診斷,亦能指導(dǎo)兒童內(nèi)分泌疾病某些藥物的臨床應(yīng)用和成人身高預(yù)測(cè)。
目前國(guó)內(nèi)外常用的骨齡評(píng)估法有Greulich-Pyle手腕骨齡圖譜法,Tanner-Whiterhouse手腕骨齡評(píng)分法(TW2),中國(guó)人骨(手腕)成熟度評(píng)分法,近來(lái)又推出TW3骨齡評(píng)估法,以骨齡預(yù)測(cè)終身高有相應(yīng)的BP、TW2-葉氏、CHN及TW3方法。本文試以GP骨齡圖譜及其骨齡作為標(biāo)準(zhǔn)[1],比較用其他三種方法對(duì)其骨齡再評(píng)估的方法差異性。此外又對(duì)三種常見(jiàn)內(nèi)分泌疾病隨訪有近似成人終身高(NAH)者,比較以不同方法骨齡評(píng)估及其相應(yīng)的終身高預(yù)測(cè)(PHA)法所測(cè)結(jié)果與NAH的差異性。
1 資料與方法
1.1 一般資料 GP圖譜中骨齡自出生至18~19歲共47張骨齡圖譜(男26例,女21例),另有男10例,女10例在上海瑞金醫(yī)院兒科內(nèi)分泌隨訪的兒童(其中矮小組10例,性早熟組5例,Turner綜合征組5例),經(jīng)隨訪已獲實(shí)際近似終身高者;實(shí)際近似終身高(ANH)的確定:隨訪時(shí)上一年身高增長(zhǎng)1.5cm和(或)骨齡達(dá)15歲(女)或16歲(男),終訪時(shí)青春發(fā)育已達(dá)Tanner Ⅳ~Ⅴ期。
1.2
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